Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | PCK1 | P35558 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952800 | 1.00 | TP53 (0.39) | TP53GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6948638 | 0.90 | MAPT (0.47) | TP53GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7999792 | 0.90 | GAA (0.39) | TP53GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6948635 | 0.90 | MAPT (0.47) | TP53GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL8008976 | 0.90 | GAA (0.39) | TP53GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6952770 | 0.89 | MAPT (0.41) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6952774 | 0.89 | MAPT (0.41) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6944940 | 0.87 | ALDH1A1 (0.43) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6944935 | 0.87 | ALDH1A1 (0.43) | GAAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8425488 | 0.86 | MEN1 (0.45) | TP53GAAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | claimed |