Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947880 | 1.00 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6946683 | 0.93 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6947761 | 0.91 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6947796 | 0.91 | CYP3A4 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6953685 | 0.90 | CYP3A4 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6952143 | 0.90 | CYP3A4 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6946694 | 0.89 | CYP3A4 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6945023 | 0.88 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6712827 | 0.88 | CYP3A4 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6651378 | 0.88 | REN (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633881-B1 | AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUED HYDROCARBONS | NARHEX LTD (HK) | 2003-10-29 | — | — | EP | claimed |
| US-6258806-B1 | PEPTIDES WITH CYCLIC DIAZAALKANES FOR PREVENTION OF PREMATURE METABOLISM METHOD FOR INHIBITING AN HIV PROTEASE IN A MAMMAL IN NEED OF SUCH PROTEASE INHIBITION, COMPRISING ADMINISTERING TO SAID MAMMAL AN EFFECTIVE DOSAGE | NARHEX LIMITED (HK) | 2001-07-10 | — | — | US | disclosed |