Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.52 |
| ▸ | ITGAV | P06756 | 2/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953267 | 1.00 | ITGB3 (0.52) | ITGB3ITGA2BITGAVSRD5A1SRD5A2 | |
| SCHEMBL6673332 | 0.87 | ITGB3 (0.56) | ITGB3ITGA2BITGAVSRD5A1SRD5A2 | |
| SCHEMBL6679291 | 0.87 | ITGB3 (0.56) | ITGB3ITGA2BITGAVSRD5A1SRD5A2 | |
| SCHEMBL6948601 | 0.82 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL6948600 | 0.82 | ITGB3 (0.61) | ITGB3ITGA2BITGAV | |
| SCHEMBL7541901 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BITGAVALDH1A1MAPT | |
| SCHEMBL6679721 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BSRD5A1SRD5A2LMNA | |
| SCHEMBL6679726 | 0.79 | ITGB3 (0.51) | ITGB3ITGA2BSRD5A1SRD5A2LMNA | |
| SCHEMBL7441878 | 0.78 | ITGB3 (0.53) | ITGB3ITGA2BITGAV | |
| SCHEMBL6676168 | 0.78 | ITGB3 (0.56) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674623-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |