SCHEMBL695351

SCHEMBL695351

O=C(O)C1CC(S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CTSS P25774 17/20 0.64
CTSL P07711 2/20 0.64
CTSK P43235 2/20 0.64
CTSB P07858 1/20 0.64
ENPP2 Q13822 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL695350 1.00 CTSS (0.64) CTSSCTSLCTSKCTSBENPP2
SCHEMBL697156 0.89 CTSS (0.65) CTSSCTSLCTSKCTSBENPP2
SCHEMBL697158 0.89 CTSS (0.65) CTSSCTSLCTSKCTSBENPP2
SCHEMBL697157 0.89 CTSS (0.65) CTSSCTSLCTSKCTSBENPP2
SCHEMBL695624 0.85 CTSS (0.65) CTSSCTSLCTSKCTSB
SCHEMBL696826 0.85 CTSS (0.59) CTSSCTSLCTSKCTSB
SCHEMBL695466 0.84 CTSS (0.64) CTSSCTSLCTSKCTSB
SCHEMBL695509 0.83 CTSS (0.60) CTSSCTSLCTSKCTSB
SCHEMBL696749 0.82 CTSS (0.63) CTSSCTSLCTSKCTSB
SCHEMBL696748 0.82 CTSS (0.63) CTSSCTSLCTSKCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2782903-A1 NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN F.HOFFMANN-LA ROCHE AG (CH) 2014-10-01 EP claimed
WO-2013076063-A1 NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN F. HOFFMANN-LA ROCHE AG (CH) 2013-05-30 WO claimed
EP-2782903-A1 NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN F.HOFFMANN-LA ROCHE AG (CH) 2014-10-01 EP disclosed
WO-2013076063-A1 NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN F. HOFFMANN-LA ROCHE AG (CH) 2013-05-30 WO disclosed
EP-2421826-A1 PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS F. Hoffmann-La Roche AG (CH) 2012-02-29 EP disclosed
WO-2010121918-A1 PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2010-10-28 WO disclosed