SCHEMBL6954022

SCHEMBL6954022

O=c1oc(-c2ccccc2)cc(O)c1SCc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.53
MAPT P10636 1/20 0.53
CYP19A1 P11511 2/20 0.46
CREB1 P16220 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TERT O14746 1/20 0.45
GSTP1 P09211 2/20 0.44
PRKDC P78527 1/20 0.43
MAOB P27338 3/20 0.43
MCL1 Q07820 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
CYP2C19 P33261 1/20 0.43
PTGS2 P35354 1/20 0.43
SLC6A3 Q01959 1/20 0.43
HIF1A Q16665 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
SLC16A3 O15427 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965173 0.90 ABCB1 (0.52) ABCB1MAPTCYP19A1CREB1TERT
SCHEMBL6954786 0.88 SMN1; SMN2 (0.50) ABCB1MAPTCYP19A1CREB1L3MBTL1
SCHEMBL6952547 0.87 ABCB1 (0.50) ABCB1MAPTCREB1L3MBTL1GSTP1
SCHEMBL6956208 0.86 NTRK1 (0.48) ABCB1MAPTCYP19A1L3MBTL1MAOB
SCHEMBL6954509 0.85 NPC1 (0.47) ABCB1MAPTCYP19A1CREB1L3MBTL1
SCHEMBL6958649 0.84 NTRK1 (0.51) ABCB1MAPTCYP19A1MAOBLMNA
SCHEMBL6964708 0.82 POLB (0.45) ABCB1MAPTCREB1L3MBTL1MAOB
SCHEMBL6960796 0.82 TNKS (0.47) ABCB1MAPTCYP19A1L3MBTL1TERT
SCHEMBL6959313 0.81 POLB (0.50) ABCB1MAPTCREB1L3MBTL1LMNA
SCHEMBL6964680 0.81 DAO (0.46) ABCB1MAPTCYP19A1CREB1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed