SCHEMBL6958649

SCHEMBL6958649

COc1ccc(-c2cc(O)c(SCc3ccccc3)c(=O)o2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 1/20 0.51
NTRK2 Q16620 1/20 0.51
MAPT P10636 4/20 0.49
ALDH1A1 P00352 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
KDM4E B2RXH2 2/20 0.49
HPGD P15428 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
CYP3A4 P08684 4/20 0.46
MAOB P27338 3/20 0.46
TNKS O95271 3/20 0.46
NPC1 O15118 3/20 0.46
TP53 P04637 3/20 0.46
LMNA P02545 2/20 0.46
KCNA5 P22460 2/20 0.46
RAB9A P51151 2/20 0.46
KCNH2 Q12809 2/20 0.46
GLA P06280 1/20 0.46
THRB P10828 1/20 0.46
NLRP3 Q96P20 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6956208 0.95 NTRK1 (0.48) NTRK1NTRK2MAPTALDH1A1SMN1; SMN2
SCHEMBL6965060 0.89 CYP3A4 (0.46) NTRK1NTRK2MAPTALDH1A1SMN1; SMN2
SCHEMBL6958533 0.89 DAO (0.47) NTRK1NTRK2MAPTALDH1A1HPGD
SCHEMBL6954786 0.88 SMN1; SMN2 (0.50) NTRK2MAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL6963367 0.87 POLB (0.45) MAPTALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL6954509 0.87 NPC1 (0.47) MAPTALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL6959999 0.86 NTRK1 (0.46) NTRK1NTRK2MAPTALDH1A1SMN1; SMN2
SCHEMBL6964365 0.84 PTGES (0.47) MAPTALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL6964213 0.84 POLB (0.44) MAPTALDH1A1SMN1; SMN2KDM4EHPGD
SCHEMBL6954022 0.84 ABCB1 (0.53) MAPTMAOBLMNAPTGS2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed