Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862956 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL610705 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL10121582 | 0.81 | HPGD (0.38) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL611439 | 0.78 | CHRNB2 (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL262092 | 0.75 | HCRTR1 (0.36) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL262093 | 0.75 | HCRTR1 (0.36) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL607998 | 0.74 | NPC1 (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL21503638 | 0.71 | ALOX5AP (0.34) | CHRNB2CHRNA4HCRTR1 | |
| SCHEMBL608698 | 0.68 | HPGD (0.36) | — | |
| SCHEMBL619863 | 0.67 | CHRNB2 (0.38) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421850-A1 | 3 -AZABICYCLO [4.1.0]HEPTANES USED AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122151-A1 | 3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |