Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 9/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696500 | 0.82 | ALDH1A1 (0.55) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL5580411 | 0.81 | MAPT (0.53) | ALDH1A1KDM4EMAPTTDP1HDAC4 | |
| SCHEMBL10540003 | 0.78 | ALDH1A1 (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL23880593 | 0.78 | ALDH1A1 (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL9576912 | 0.77 | CYP3A4 (0.47) | ALDH1A1KDM4EUSP2MAPTTDP1 | |
| SCHEMBL7366475 | 0.77 | ALDH1A1 (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL4077294 | 0.77 | ALDH1A1 (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL7365630 | 0.77 | ALDH1A1 (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL5750458 | 0.77 | ALDH1A1 (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL8039491 | 0.77 | ALDH1A1 (0.59) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887344-B1 | Quinolines and quinazolines useful in therapy | PFIZER LTD (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |