Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 16/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954810 | 1.00 | FDFT1 (0.47) | FDFT1ALDH1A1MDM2 | |
| SCHEMBL6954797 | 1.00 | FDFT1 (0.47) | FDFT1ALDH1A1MDM2 | |
| SCHEMBL6952888 | 0.92 | FDFT1 (0.55) | FDFT1MDM2 | |
| SCHEMBL6952893 | 0.92 | FDFT1 (0.55) | FDFT1MDM2 | |
| SCHEMBL4116107 | 0.92 | FDFT1 (0.55) | FDFT1MDM2 | |
| SCHEMBL8501265 | 0.87 | FDFT1 (0.53) | FDFT1MDM2 | |
| SCHEMBL8501268 | 0.87 | FDFT1 (0.53) | FDFT1MDM2 | |
| SCHEMBL8799010 | 0.87 | FDFT1 (0.42) | FDFT1ALDH1A1MDM2 | |
| SCHEMBL6954208 | 0.87 | FDFT1 (0.44) | FDFT1ALDH1A1 | |
| SCHEMBL6954198 | 0.87 | FDFT1 (0.44) | FDFT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5885979-A | SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5726306-A | INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |