Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 8/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 8/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967267 | 0.86 | MAPK14 (0.50) | MAPK14CSNK1DCSNK1ETGFBR1MAPK13 | |
| SCHEMBL6880496 | 0.85 | MAPK14 (0.54) | MAPK14CSNK1DCSNK1EEGFRTGFBR1 | |
| SCHEMBL7890787 | 0.84 | MAPK14 (0.53) | MAPK14CSNK1DCSNK1EEGFRTGFBR1 | |
| SCHEMBL4913562 | 0.84 | MAPK14 (0.65) | MAPK14CSNK1DCSNK1EEGFRTGFBR1 | |
| SCHEMBL5574428 | 0.82 | MAPK14 (0.69) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL22730370 | 0.80 | MAPK14 (0.61) | MAPK14 | |
| SCHEMBL6950452 | 0.79 | MAPK14 (0.71) | MAPK14 | |
| SCHEMBL22730361 | 0.79 | MAPK14 (0.71) | MAPK14 | |
| SCHEMBL7884407 | 0.78 | MAPK14 (0.68) | MAPK14CSNK1DCSNK1EEGFRTGFBR1 | |
| SCHEMBL3668786 | 0.78 | EGFR (0.57) | MAPK14CSNK1DCSNK1EEGFRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1130358-C | Imidazole compound and preparation method and application thereof | SMITHKLINE BEECHAM CORP (US) | 2003-12-10 | — | — | CN | disclosed |
| EP-1314728-A1 | Pyridyl and pyrimidinyl imines as intermediates for imidazole derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6218537-B1 | Process for making pyridyl and pyrimidine substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION | 2001-04-17 | — | — | US | disclosed |
| US-5869660-A | Process of preparing imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| US-5739143-A | Imidazole compounds and compositions | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-14 | — | — | US | disclosed |
| US-5658903-A | Imidazole compounds, compositions and use | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |