Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890787 | 0.89 | MAPK14 (0.53) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL6955880 | 0.86 | MAPK14 (0.54) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL6880496 | 0.85 | MAPK14 (0.54) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL6950452 | 0.85 | MAPK14 (0.71) | MAPK14 | |
| SCHEMBL4913562 | 0.84 | MAPK14 (0.65) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL4915292 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7884407 | 0.78 | MAPK14 (0.68) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL22730495 | 0.78 | MAPK14 (0.71) | MAPK14 | |
| SCHEMBL3668786 | 0.78 | EGFR (0.57) | MAPK14TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL6423015 | 0.78 | MAPK14 (0.60) | MAPK14TGFBR1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900083-B1 | NOVEL SUBSTITUTED IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-08-20 | — | — | EP | disclosed |
| US-5977103-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| US-5864036-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |
| US-5756499-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |