Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 17/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 17/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.41 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955021 | 1.00 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BCCRL2CCR2 | |
| SCHEMBL6959581 | 1.00 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BCCRL2CCR2 | |
| SCHEMBL7969406 | 0.94 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7969403 | 0.94 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BDRD2 | |
| Hydrochloric Acid SCHEMBL7968852 | 0.93 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BDRD2 | |
| Hydrochloric Acid SCHEMBL7968851 | 0.93 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6965559 | 0.90 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BCCRL2CCR2 | |
| SCHEMBL7955554 | 0.90 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BCCRL2CCR2 | |
| Hydrochloric Acid SCHEMBL6956543 | 0.89 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BCCRL2CCR2 | |
| SCHEMBL7971217 | 0.89 | ADRA1D (0.43) | ADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |