Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.40 |
| ▸ | CTSL | P07711 | 7/20 | 0.40 |
| ▸ | CTSB | P07858 | 5/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696865 | 0.94 | CTSS (0.41) | CTSSCTSLCTSBCTSKUCHL1 | |
| SCHEMBL707038 | 0.87 | CTSS (0.46) | CTSSCTSLCTSBCTSK | |
| SCHEMBL696265 | 0.87 | CTSS (0.46) | CTSSCTSLCTSBCTSK | |
| SCHEMBL697169 | 0.86 | CTSS (0.50) | CTSSCTSLCTSB | |
| SCHEMBL695061 | 0.85 | CTSS (0.44) | CTSSCTSLCTSBCTSKSTS | |
| SCHEMBL693997 | 0.85 | CTSS (0.48) | CTSSCTSLCTSBCTSKUCHL1 | |
| SCHEMBL696140 | 0.84 | CTSS (0.51) | CTSSCTSLCTSB | |
| SCHEMBL697655 | 0.84 | CTSS (0.38) | CTSSCTSLCTSBCTSKUCHL1 | |
| SCHEMBL694346 | 0.83 | STS (0.44) | CTSSCTSLCTSBCTSKUCHL1 | |
| SCHEMBL697234 | 0.82 | CTSS (0.55) | CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | claimed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | claimed |
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |