Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952157 | 0.88 | ALDH1A1 (0.67) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6962436 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6962182 | 0.85 | SMN1; SMN2 (0.57) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6958790 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6963088 | 0.82 | MAPT (0.59) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6962676 | 0.82 | KMT2A (0.54) | ALDH1A1HTTRAB9ASMN1; SMN2MAPT | |
| SCHEMBL6964216 | 0.82 | MAPT (0.51) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6962605 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6962738 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6958093 | 0.81 | KMT2A (0.50) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |