Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 17/20 | 0.61 |
| ▸ | MMP1 | P03956 | 11/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960323 | 0.91 | MMP3 (0.74) | MMP3MMP1MMP2 | |
| SCHEMBL6951442 | 0.90 | MMP3 (0.65) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6956485 | 0.90 | MMP3 (0.65) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6957313 | 0.90 | MMP3 (0.63) | MMP3MMP1MMP2CA1CA2 | |
| SCHEMBL6956634 | 0.89 | MMP3 (0.66) | MMP3MMP1MMP2ACECA1 | |
| SCHEMBL6951172 | 0.83 | MMP3 (0.76) | MMP3MMP1MMP2 | |
| SCHEMBL6950430 | 0.83 | MMP3 (0.76) | MMP3MMP1MMP2 | |
| SCHEMBL6951176 | 0.83 | MMP3 (0.76) | MMP3MMP1MMP2 | |
| SCHEMBL6956848 | 0.82 | MMP3 (0.66) | MMP3MMP1MMP2CA1 | |
| SCHEMBL6956147 | 0.76 | MMP3 (1.00) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900211-B1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | UPJOHN CO (US) | 2003-07-02 | — | — | EP | claimed |