Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177432 | 0.87 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL7907044 | 0.84 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4593648 | 0.84 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6958734 | 0.83 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL8439511 | 0.82 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4916626 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL7608455 | 0.77 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6955789 | 0.74 | MAPK14 (0.73) | MAPK14CSNK1DCSNK1E | |
| SCHEMBL7950076 | 0.71 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4593520 | 0.71 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314728-A1 | Pyridyl and pyrimidinyl imines as intermediates for imidazole derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6218537-B1 | Process for making pyridyl and pyrimidine substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0831830-A4 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0831830-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5658903-A | Imidazole compounds, compositions and use | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996040143-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |