Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640914 | 0.79 | TGFBR1 (0.46) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1640844 | 0.75 | MAPK14 (0.44) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL1640318 | 0.74 | TGFBR1 (0.58) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL6953086 | 0.73 | MAPK14 (0.64) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL7942534 | 0.73 | MAPK14 (0.50) | MAPK14TGFBR1 | |
| SCHEMBL8177432 | 0.72 | MAPK14 (0.72) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL7950070 | 0.72 | MAPK14 (0.58) | MAPK14CSNK1DCSNK1EEGFR | |
| SCHEMBL4916626 | 0.72 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6958734 | 0.71 | MAPK14 (0.62) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6957542 | 0.71 | MAPK14 (0.65) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255491-B1 | CHEMICAL INTERMEDIATES SUCH AS 1-(SUBSTITUTED), 4-ARYL, 5-(3-N,N-DISUBSTITUTED AMINO-1-PROPENONE) IMIDAZOLE, USEFUL FOR MAKING 5-PYRIMIDINYL IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION | 2001-07-03 | — | — | US | disclosed |
| US-6239279-B1 | THERAPY FOR CYTOKINE SENSITIVE DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-05-29 | — | — | US | disclosed |
| US-6100399-A | Synthesis for 4-aryl-5-pyrimidine imidazole substituted compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-08 | — | — | US | disclosed |
| US-5917043-A | INTERMEDIATES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |