Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGAV | P06756 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263638 | 0.99 | TDP1 (0.51) | STK17BSTK17ATDP1BRD4CYP3A4 | |
| SCHEMBL6300342 | 0.97 | STK17B (0.52) | STK17BSTK17ATDP1BRD4CYP3A4 | |
| SCHEMBL6174559 | 0.92 | BCHE (0.54) | STK17BSTK17ABRD4CYP3A4ITGB3 | |
| SCHEMBL4400612 | 0.85 | POLB (0.58) | TDP1CYP3A4ALOX12HTTSMN1; SMN2 | |
| SCHEMBL4398713 | 0.83 | POLB (0.58) | ALOX12HTTSMN1; SMN2 | |
| SCHEMBL30475386 | 0.82 | TDP1 (0.56) | STK17BSTK17ATDP1BRD4CYP3A4 | |
| SCHEMBL3146288 | 0.81 | GAA (0.54) | TDP1HTTSMN1; SMN2 | |
| SCHEMBL12199203 | 0.81 | ITGB3 (0.49) | ITGB3ITGAVHTTSMN1; SMN2ITGB1 | |
| SCHEMBL7415378 | 0.80 | TLR8 (0.54) | ITGB3ITGAVHTTSMN1; SMN2ITGB1 | |
| SCHEMBL22241695 | 0.80 | PCSK9 (0.62) | ITGB3ITGAVHTTSMN1; SMN2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102587-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6458814-B1 | VITRONECTIN RECEPTOR ANTAGONISTS AND ARE USEFUL IN THE TREATMENT OF OSTEOPOROSIS: TREATMENT OF INFLAMMATION, CANCER AND CARDIOVASCULAR DISORDERS, SUCH AS ATHEROSCLEROSIS AND RESTENOSIS, AND DISEASES WHEREIN BONE RESORPTION IS A FACTOR, | SMITHKLINE BEECHAM CORPORATION | 2002-10-01 | — | — | US | disclosed |
| CN-1322133-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | CN | disclosed |
| EP-1102587-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007544-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |