Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17180554 | 0.80 | TAAR1 (0.38) | CYP1A2KMT2ABRD4AKT2TDO2 | |
| SCHEMBL4586886 | 0.79 | SMN1; SMN2 (0.36) | CYP1A2KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL2874737 | 0.79 | CYP1A2 (0.41) | CYP1A2MAPTTDP1KDM4EALDH1A1 | |
| SCHEMBL439377 | 0.79 | BRD4 (0.37) | KMT2ABRD4AKT2TDO2MAPT | |
| SCHEMBL9800413 | 0.78 | ALDH1A1 (0.35) | KMT2AMAPTMEN1TDP1KDM4E | |
| SCHEMBL7070227 | 0.78 | BRD4 (0.36) | KMT2ABRD4AKT2TDO2MAPT | |
| SCHEMBL5182645 | 0.76 | CYP1A2 (0.38) | CYP1A2MAPTALDH1A1L3MBTL1HTT | |
| SCHEMBL10410188 | 0.76 | GRIA1 (0.38) | CYP1A2ALDH1A1L3MBTL1GAALMNA | |
| SCHEMBL5676543 | 0.76 | KMT2A (0.40) | CYP1A2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL14142280 | 0.76 | CYP1A2 (0.34) | CYP1A2AKT2MAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353907-A2 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002074726-A2 | ANILINE DERIVATIVES USEFUL AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-09-26 | — | — | WO | disclosed |
| EP-0406839-B1 | Process for the preparation of 1-(4-tetrahydropyranyl) or 1-(4-tetrahydrothiopyranyl)-prop-1-en-3-ones | BASF AG (DE) | 1995-02-01 | — | — | EP | disclosed |
| EP-0406839-A2 | Process for the preparation of 1-(4-tetrahydropyranyl) or 1-(4-tetrahydrothiopyranyl)-prop-1-en-3-ones | BASF Aktiengesellschaft (DE) | 1991-01-09 | — | — | EP | disclosed |
| EP-0096789-A1 | Water-insoluble monoazo dyestuffs, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1983-12-28 | — | — | EP | disclosed |