Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 12/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL695516 | 0.99 | CTSS (0.45) | CTSSP2RX7CTSLCTSBEPHX2 | |
| Hydrochloric Acid SCHEMBL697085 | 0.83 | CTSS (0.56) | CTSSCTSLCTSB | |
| SCHEMBL702312 | 0.78 | CTSS (0.51) | CTSSCTSLCTSB | |
| Hydrochloric Acid SCHEMBL696385 | 0.77 | CTSS (0.50) | CTSSCTSLCTSB | |
| SCHEMBL697725 | 0.77 | CTSS (0.74) | CTSSCTSLCTSB | |
| Hydrochloric Acid SCHEMBL694102 | 0.76 | CTSS (0.72) | CTSSCTSLCTSB | |
| SCHEMBL694969 | 0.76 | CTSS (0.43) | CTSSCTSLCTSBALDH1A1 | |
| SCHEMBL15327131 | 0.76 | CTSS (0.43) | CTSSCTSLCTSBALDH1A1 | |
| SCHEMBL15327130 | 0.76 | CTSS (0.43) | CTSSCTSLCTSBALDH1A1 | |
| SCHEMBL695867 | 0.75 | CTSS (0.68) | CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | claimed |
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |