Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 10/20 | 0.58 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13369610 | 0.81 | CXCR1 (0.44) | TAAR1PNMTHTR1AADRA2ASLC6A2 | |
| SCHEMBL6953644 | 0.76 | TAAR1 (0.62) | TAAR1PNMTCYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL11791298 | 0.73 | HSD17B10 (0.39) | HTR1AADRA2ASLC6A2CYP2C19KDM4E | |
| SCHEMBL1570203 | 0.73 | TAAR1 (1.00) | TAAR1PNMTALDH1A1BACE1DPP4 | |
| SCHEMBL13590951 | 0.73 | TAAR1 (0.58) | TAAR1PNMTALDH1A1CYP1A2 | |
| SCHEMBL5159116 | 0.72 | TAAR1 (0.45) | TAAR1PNMTKDM4EBLMKMT2A | |
| SCHEMBL20093628 | 0.71 | HSD17B10 (0.38) | HTR1AADRA2ASLC6A2CYP2C19KDM4E | |
| SCHEMBL20103788 | 0.71 | TAAR1 (0.59) | TAAR1PNMTBACE1 | |
| SCHEMBL3922168 | 0.70 | TAAR1 (0.64) | TAAR1PNMTDPP4HSP90AA1ACHE | |
| SCHEMBL2935032 | 0.68 | DPP4 (0.52) | CYP2C19ALDH1A1KMT2ATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |