Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.62 |
| ▸ | PNMT | P11086 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103788 | 0.84 | TAAR1 (0.59) | TAAR1PNMTMAOBKRAS | |
| SCHEMBL1765193 | 0.79 | PNMT (0.48) | TAAR1PNMTCYP2A6HTR2ALOXL2 | |
| SCHEMBL1570203 | 0.77 | TAAR1 (1.00) | TAAR1PNMTMAOBHTR2ASMN1; SMN2 | |
| SCHEMBL6958133 | 0.76 | TAAR1 (0.58) | TAAR1PNMTSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL13590951 | 0.76 | TAAR1 (0.58) | TAAR1PNMTMAOBKRASCYP2A6 | |
| SCHEMBL17552720 | 0.75 | TAAR1 (0.34) | TAAR1PNMTCYP2A6SMN1; SMN2CYP3A4 | |
| SCHEMBL1005529 | 0.75 | TAAR1 (0.34) | TAAR1PNMTCYP2A6CYP3A4 | |
| SCHEMBL10830911 | 0.75 | TAAR1 (0.34) | TAAR1PNMTCYP2A6CYP3A4 | |
| SCHEMBL3414586 | 0.75 | CYP3A4 (0.39) | TAAR1SMN1; SMN2CYP3A4TSHR | |
| SCHEMBL10061023 | 0.75 | ALDH1A1 (0.35) | TAAR1PNMTSIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |