Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | CEL | P19835 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2151198 | 0.86 | CYP1A2 (0.39) | CYP1A2SIGMAR1CELEPHX1HPGD | |
| SCHEMBL6579197 | 0.84 | CYP1A2 (0.36) | CYP1A2SIGMAR1CELEPHX1HPGD | |
| SCHEMBL17645782 | 0.79 | CYP1A2 (0.31) | CYP1A2 | |
| SCHEMBL4896518 | 0.78 | CYP1A2 (0.46) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| Ammonia Solution, Strong SCHEMBL8491678 | 0.77 | CYP1A2 (0.45) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| SCHEMBL19102714 | 0.76 | CYP1A2 (0.48) | CYP1A2SIGMAR1CEL | |
| SCHEMBL6114858 | 0.76 | CYP1A2 (0.43) | CYP1A2SIGMAR1EPHX1KDM5APHF8 | |
| SCHEMBL20995382 | 0.74 | CYP1A2 (0.52) | CYP1A2SIGMAR1EPHX1MEN1USP2 | |
| SCHEMBL17803560 | 0.74 | — | — | |
| SCHEMBL5614191 | 0.72 | SIGMAR1 (0.70) | CYP1A2SIGMAR1CELEPHX1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882023-B1 | HISTAMINE H 3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2003-06-04 | — | — | EP | disclosed |
| US-6080871-A | ANTIHISTAMINES | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0882023-A1 | HISTAMINE H 3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997029092-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1997-08-14 | — | — | WO | disclosed |