Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10589844 | 0.81 | ADORA2A (0.44) | GCGRDHODHADORA2AADORA2BADORA1 | |
| SCHEMBL8880213 | 0.81 | HMGCR (0.50) | GCGRDHODH | |
| SCHEMBL6963687 | 0.77 | GCGR (0.62) | GCGR | |
| SCHEMBL6957662 | 0.75 | ADORA2A (0.43) | GCGRADORA2AADORA2BADORA1 | |
| SCHEMBL9261621 | 0.75 | ALDH1A1 (0.49) | — | |
| SCHEMBL25510510 | 0.74 | ADORA2A (0.40) | GCGRADORA2AADORA2BADORA1 | |
| SCHEMBL6951556 | 0.73 | KDM4E (0.40) | — | |
| SCHEMBL2648203 | 0.73 | GCGR (0.65) | GCGR | |
| SCHEMBL6956576 | 0.72 | GCGR (0.46) | GCGRDHODH | |
| SCHEMBL4449474 | 0.72 | GCGR (0.63) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325130-B1 | Substituted pyridines | BAYER AG (DE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1123924-A1 | Substituted pyridines as HMG-COA reductase inhibitors | BAYER AG (DE) | 2001-08-16 | — | — | EP | disclosed |
| EP-1123925-A1 | Process for preparation of substituted pyridines | BAYER AG (DE) | 2001-08-16 | — | — | EP | disclosed |
| CN-1274719-A | Process for preparation of substituted pyridine compound | BAYER AG (DE) | 2000-11-29 | — | — | CN | disclosed |
| CN-1055684-C | Process for preparing substituted pyridine compounds | BAYER AG (DE) | 2000-08-23 | — | — | CN | disclosed |
| US-5401746-A | FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND HMG-COA REDUCTASE | BAYER AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5169857-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-08 | — | — | US | disclosed |
| US-5006530-A | Certain 7-[2,6-diisopropyl-4-phenyl-5-lower alkoxymethyl-pyrid-3-yl]-3,5-dihydroxy-6-enoates and derivatives useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-09 | — | — | US | disclosed |
| CN-1034364-A | Substituted pyridines and process for their preparation | BAYER AG (DE) | 1989-08-02 | — | — | CN | disclosed |
| EP-0325130-A2 | Substituted pyridines | BAYER AG (DE) | 1989-07-26 | — | — | EP | disclosed |