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Sugi Predict / Compounds / SCHEMBL6959137

SCHEMBL6959137

SCHEMBL6959137

COc1cc(CO[C@H]2CN(OC(=O)OC(C)(C)C)C[C@@H](OCc3cc(OC)c(OC)c(OC)c3)[C@H]2c2ccc(OCCCOCc3ccccc3)cc2)cc(OC)c1OC

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 16/20 0.43
▸ PDE4B Q07343 1/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6959740 0.96 REN (0.46) RENPDE4BL3MBTL1
SCHEMBL6956272 0.91 REN (0.45) RENPDE4BL3MBTL1
SCHEMBL6954117 0.90 REN (0.47) RENL3MBTL1
SCHEMBL6954988 0.89 REN (0.46) RENPDE4BL3MBTL1
SCHEMBL7078376 0.89 REN (0.51) RENPDE4BL3MBTL1
SCHEMBL6951457 0.89 REN (0.45) RENPDE4B
SCHEMBL6955866 0.88 REN (0.45) REN
SCHEMBL6951105 0.88 REN (0.47) RENL3MBTL1
SCHEMBL7082808 0.87 REN (0.47) RENL3MBTL1
SCHEMBL6956038 0.87 REN (0.48) RENPDE4BL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863875-B1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY HOFFMANN LA ROCHE (CH) 2003-06-04 — — EP disclosed
EP-0863875-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1998-09-16 — — EP disclosed
WO-1997009311-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1997-03-13 — — WO disclosed