SCHEMBL6959201

SCHEMBL6959201

CCCCc1ncc(C=C(Cc2ccncc2)C(=O)O)n1Cc1ccccc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL683468 1.00 AGTR1 (0.75) AGTR1
SCHEMBL9424090 0.94
SCHEMBL9424094 0.94
SCHEMBL10442005 0.91
SCHEMBL10442003 0.91
SCHEMBL9489974 0.91
SCHEMBL9424164 0.90
SCHEMBL9424158 0.90
SCHEMBL9424389 0.89
SCHEMBL9424382 0.89

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0955294-A2 Imidazolyl-alkenoic acid SMITHKLINE BEECHAM CORPORATION (US) 1999-11-10 EP claimed
US-5185351-A Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma SMITHKLINE BEECHAM CORPORATION (US) 1993-02-09 US claimed
EP-0403159-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP claimed
EP-0955294-B1 Imidazolyl-alkenoic acid SMITHKLINE BEECHAM CORP (US) 2003-09-24 EP disclosed
EP-0955294-A2 Imidazolyl-alkenoic acid SMITHKLINE BEECHAM CORPORATION (US) 1999-11-10 EP disclosed
US-5418250-A Hypotensive SMITHKLINE BEECHAM CORPORATION (US) 1995-05-23 US disclosed
EP-0641203-A1 IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORPORATION (US) 1995-03-08 EP disclosed
EP-0641203-A4 IMIDAZOLYL-ALKENOIC ACIDS. SMITHKLINE BEECHAM CORP (US) 1994-06-09 EP disclosed
EP-0425211-B1 Substituted 5-((tetrazolyl)alkenyl)-imidazoles SMITHKLINE BEECHAM CORP (US) 1994-03-30 EP disclosed
WO-1993003722-A1 IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORPORATION (US) 1993-03-04 WO disclosed
US-5185351-A Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma SMITHKLINE BEECHAM CORPORATION (US) 1993-02-09 US disclosed
US-5177096-A Angiotensin II receptor antagonist SMITHKLINE BEECHAM CORPORATION (US) 1993-01-05 US disclosed
EP-0425211-A1 Substituted 5-((tetrazolyl)alkenyl)-imidazoles SMITHKLINE BEECHAM CORPORATION (US) 1991-05-02 EP disclosed
EP-0403159-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed