SCHEMBL6959440

SCHEMBL6959440

CNC(=O)c1ccc(C=CC(=O)O)cc1OC

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.66
HSD17B10 Q99714 4/20 0.66
ALDH1A1 P00352 4/20 0.66
HPGD P15428 3/20 0.66
ALOX15 P16050 2/20 0.66
MAPK1 P28482 2/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
PKM P14618 3/20 0.62
SNCA P37840 3/20 0.62
CA12 O43570 2/20 0.62
CA1 P00915 2/20 0.62
CA2 P00918 2/20 0.62
CA3 P07451 2/20 0.62
CA4 P22748 2/20 0.62
CA6 P23280 2/20 0.62
CA5A P35218 2/20 0.62
CA7 P43166 2/20 0.62
CA9 Q16790 2/20 0.62
CA14 Q9ULX7 2/20 0.62
CA5B Q9Y2D0 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6959438 1.00 KDM4E (0.66) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL6954731 0.89 EPHX2 (0.65) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL6954729 0.89 EPHX2 (0.65) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL4240795 0.85 KDM4E (0.69) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL4240801 0.85 KDM4E (0.69) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL3910758 0.85 KDM4E (0.73) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL3910762 0.85 KDM4E (0.73) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL7661413 0.83 XDH (0.60) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL7661406 0.82 EPHX2 (0.46) KDM4EHSD17B10ALDH1A1HPGDALOX15
SCHEMBL7661408 0.82 EPHX2 (0.46) KDM4EHSD17B10ALDH1A1HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0879233-B1 CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-08-13 EP disclosed
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6127389-A TREATMENT OF HYPERTENSION, RENAL DISEASES, HEART FAILURE, HYPERTENSION, MENIERE'S DISEASE, PERIPHERAL AND CEREBRAL CIRCULATORY DISORDERS, CLIMACTERIC DISTURBANCE, RETINOCHOROIDAL CIRCULATORY DISORDERS, MYOCARDIAL ISCHEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-10-03 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
US-6015818-A TREATING KIDNEY, BRAIN, AND CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-01-18 US disclosed
EP-0879233-A1 CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-25 EP disclosed
WO-1997028153-A1 CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-08-07 WO disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed