SCHEMBL695995

SCHEMBL695995

[c]1ccc2[nH]nc(CCc3ccccc3)c2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.40
ALDH1A1 P00352 5/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
HTT P42858 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
AR P10275 1/20 0.36
DAO P14920 1/20 0.36
NTRK1 P04629 1/20 0.35
KDM4E B2RXH2 4/20 0.35
HPGD P15428 3/20 0.35
MPO P05164 1/20 0.35
ALPL P05186 2/20 0.34
GAA P10253 1/20 0.34
IDO1 P14902 1/20 0.34
TTK P33981 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6583920 0.86 PARP1 (0.50) PARP1ALDH1A1HTTCYP3A4CYP2C9
SCHEMBL693550 0.85 NPC1 (0.39) PARP1NPC1RAB9ASMN1; SMN2DAO
SCHEMBL4850935 0.80 PDE3B (0.33)
SCHEMBL17610806 0.77 HSP90AA1 (0.33) ALDH1A1NPC1RAB9ASMN1; SMN2HTT
SCHEMBL5786090 0.76 MAP2K4 (0.33)
SCHEMBL2557892 0.76 KCNH2 (0.31) KDM4E
SCHEMBL6750522 0.74 SLC6A4 (0.35) MPOGSK3B
SCHEMBL6615346 0.73 HSP90AA1 (0.41) PARP1ARDAONTRK1MPO
SCHEMBL1129040 0.73 DCLK1 (0.56) PARP1ALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL5796193 0.72 ITK (0.48) NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421825-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP claimed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO claimed
EP-3197450-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-08-02 EP disclosed
WO-2016046130-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2016-03-31 WO disclosed
EP-2421825-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP disclosed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed