Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.65 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.65 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.65 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955155 | 0.88 | POLB (0.80) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL6958389 | 0.87 | POLB (0.81) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL6959316 | 0.86 | POLB (0.80) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL6956017 | 0.86 | POLB (0.79) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6947789 | 0.85 | POLB (0.77) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6954033 | 0.84 | POLB (0.76) | POLBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL7132512 | 0.83 | POLB (0.75) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9503033 | 0.83 | CACNA1F (0.80) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9022136 | 0.82 | CACNA1F (0.79) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL6954075 | 0.82 | POLB (0.93) | POLBKDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |