Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958389 | 0.90 | POLB (0.81) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL6959316 | 0.89 | POLB (0.80) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL6956017 | 0.88 | POLB (0.79) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL6960340 | 0.88 | POLB (0.76) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL6947789 | 0.87 | POLB (0.77) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL6954033 | 0.86 | POLB (0.76) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL7132512 | 0.85 | POLB (0.75) | POLBKMT2ATSHRMAPK1MEN1 | |
| SCHEMBL6954075 | 0.84 | POLB (0.93) | POLBKMT2AL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL7885845 | 0.81 | ADORA3 (0.59) | POLBKMT2AL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL6955134 | 0.81 | POLB (0.68) | POLBKMT2ATSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |