Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966294 | 0.80 | GHSR (0.43) | BRD3POLBEPHX2GHSR | |
| SCHEMBL3330730 | 0.80 | POLB (0.64) | BRD3KMT2APOLBEPHX2SMN1; SMN2 | |
| SCHEMBL3761565 | 0.80 | POLB (0.64) | BRD3KMT2APOLBEPHX2SMN1; SMN2 | |
| SCHEMBL3328247 | 0.80 | POLB (0.64) | BRD3KMT2APOLBEPHX2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2015703 | 0.78 | POLB (0.62) | BRD3KMT2APOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2021306 | 0.78 | POLB (0.62) | BRD3KMT2APOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2015072 | 0.78 | POLB (0.62) | BRD3KMT2APOLBSMN1; SMN2 | |
| SCHEMBL2146675 | 0.75 | KMT2A (0.56) | KMT2APOLB | |
| SCHEMBL2146682 | 0.75 | KMT2A (0.56) | KMT2APOLB | |
| Hydrochloric Acid SCHEMBL2146077 | 0.73 | KMT2A (0.55) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |