Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081892 | 0.94 | HTT (0.36) | HTTALDH1A1ALOX5KMT2AMAPT | |
| SCHEMBL6968844 | 0.90 | POLB (0.36) | HTTALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6966622 | 0.90 | TLR8 (0.35) | HTTALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL6965395 | 0.87 | LMNA (0.35) | HTTALDH1A1ALOX5KMT2AMAPT | |
| SCHEMBL6958518 | 0.86 | — | — | |
| SCHEMBL6969233 | 0.85 | KMT2A (0.36) | HTTALDH1A1ALOX5KMT2AMAPT | |
| SCHEMBL7081183 | 0.84 | TDP1 (0.37) | ALDH1A1TSHRNPSR1 | |
| SCHEMBL6960212 | 0.83 | HTT (0.36) | HTTALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL6965581 | 0.83 | HTT (0.36) | HTTALDH1A1MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL6965372 | 0.83 | KMT2A (0.37) | HTTALDH1A1ALOX5KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |