SCHEMBL6960726

SCHEMBL6960726

Cc1oc(-c2ccccc2)nc1COc1ccc2cc(CC3SC(=O)NC3=O)cnc2c1

nearest known ligand 0.50

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDR P35968 1/20 0.50
PPARA Q07869 13/20 0.49
PPARG P37231 12/20 0.49
FFAR1 O14842 7/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6958644 0.94 PPARG (0.50) PPARAPPARG
SCHEMBL6959897 0.92 KDR (0.47) KDRPPARAPPARGFFAR1
SCHEMBL6954966 0.91 FFAR1 (0.49) PPARAPPARGFFAR1
SCHEMBL6956104 0.90 FFAR1 (0.47) PPARAPPARGFFAR1
SCHEMBL6954182 0.89 FFAR1 (0.49) PPARAPPARGFFAR1
SCHEMBL6960528 0.88 FFAR1 (0.49) PPARAPPARGFFAR1
SCHEMBL6954017 0.88 PPARA (0.47) PPARAPPARGFFAR1
SCHEMBL6531845 0.88 PPARG (0.61) KDRPPARAPPARGFFAR1
SCHEMBL6965683 0.87 PPARG (0.43) PPARAPPARGFFAR1
SCHEMBL6965144 0.86 FFAR1 (0.50) PPARAPPARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787725-B1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO (JP) 2003-04-23 EP disclosed
EP-0787725-A1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO., LTD. (JP) 1997-08-06 EP disclosed