SCHEMBL6961273

SCHEMBL6961273

[CH2]CCCCNS(=O)(=O)c1cccc2c(N(C)C)cccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.67
HDAC10 Q969S8 1/20 0.67
HDAC6 Q9UBN7 1/20 0.67
HDAC5 Q9UQL6 1/20 0.67
GBA1 P04062 3/20 0.59
GLB1 P16278 3/20 0.59
FUCA1 P04066 1/20 0.56
EDNRA P25101 2/20 0.55
HTR1A P08908 3/20 0.54
TP53 P04637 2/20 0.54
CYP3A4 P08684 2/20 0.54
TSHR P16473 2/20 0.54
CYP2C19 P33261 2/20 0.54
NPC1 O15118 1/20 0.54
CYP2D6 P10635 1/20 0.54
THPO P40225 1/20 0.54
MTOR P42345 1/20 0.54
RAB9A P51151 1/20 0.54
HIF1A Q16665 1/20 0.54
HSD17B10 Q99714 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4139459 0.93 HDAC4 (0.75) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL4142506 0.92 HDAC4 (0.77) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL9157181 0.91 HDAC4 (0.61) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL4126957 0.90 HDAC4 (0.71) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL23964395 0.88 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL29376225 0.88 HDAC4 (0.69) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL6416691 0.87 HDAC4 (0.71) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL8294488 0.87 HDAC4 (0.71) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL12442088 0.87 HDAC4 (0.71) HDAC4HDAC10HDAC6HDAC5GBA1
SCHEMBL5384708 0.87 HDAC4 (0.67) HDAC4HDAC10HDAC6HDAC5GBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900211-B1 THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS UPJOHN CO (US) 2003-07-02 EP claimed
US-5847148-A Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation PHARMACIA & UPJOHN COMPANY (US) 1998-12-08 US claimed
EP-0900211-B1 THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS UPJOHN CO (US) 2003-07-02 EP disclosed
US-6127191-A SOLID SUPPORT HAVING PLURALITY OF PENDANT SCAFFOLD MOIETIES COVALENTLY ATTACHED; FOR SYNTHESIS OF BIOACTIVE MOLECULES 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2000-10-03 US disclosed
US-5847148-A Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation PHARMACIA & UPJOHN COMPANY (US) 1998-12-08 US disclosed
WO-1998024760-A1 AMINOBENZENEDICARBOXYLIC ACID-BASED COMBINATORIAL LIBRARIES GRAYBILL TODD L (US) 1998-06-11 WO disclosed