Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114071 | 0.98 | HTR3A (0.47) | HTR3AHTR2AHTR2CJAK3 | |
| SCHEMBL23706644 | 0.87 | — | — | |
| SCHEMBL28247554 | 0.85 | SLC18A3 (0.39) | HTR3AHTR2C | |
| SCHEMBL7501843 | 0.84 | CYP2D6 (0.38) | HTR3AHTR2AHTR2C | |
| SCHEMBL7499316 | 0.81 | — | — | |
| SCHEMBL20558178 | 0.78 | — | — | |
| SCHEMBL11440898 | 0.74 | CYP2D6 (0.31) | — | |
| SCHEMBL2145970 | 0.71 | — | — | |
| SCHEMBL11258641 | 0.71 | HRH4 (0.37) | HTR3AHTR2C | |
| SCHEMBL3764762 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831830-B1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | claimed |
| US-5563180-A | REACTING POLYISOCYANATE, POLYESTERPOLYOL IN THE PRESENCE OF BLOWING AGENT AND CATALYST; CLOSED CELL RIGID FOAM | THE CELOTEX CORPORATION (US) | 1996-10-08 | — | — | US | disclosed |
| US-5470889-A | Fire resistant roofing material | THE CELOTEX CORPORATION (US) | 1995-11-28 | — | — | US | disclosed |
| US-5405884-A | Mixture of alkali or alkaline earth metal carboxylic salt, tertiary amine and quaternary ammonium carboxylic salt | THE CELOTEX CORPORATION (US) | 1995-04-11 | — | — | US | disclosed |
| US-5308883-A | Rigid closed-cell foam from polyisocyanate and polyesterpolyol and blowing agent with catalyst | THE CELOTEX CORPORATION (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0254097-A2 | Catalyst mixtures for polyisocyanurate foam | THE CELOTEX CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |
| US-4710521-A | SALT OF CARBOXYLIC ACIDS AND TERTIARY AMINES | THE CELOTEX CORPORATION (US) | 1987-12-01 | — | — | US | disclosed |