SCHEMBL6962005

SCHEMBL6962005

Nc1cc(S(=O)(=O)c2cccc3cnccc23)c(Cl)cc1[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 3/20 0.43
CYP3A4 P08684 5/20 0.41
CYP2D6 P10635 4/20 0.41
PRKD3 O94806 4/20 0.41
PRKCG P05129 4/20 0.41
PRKCB P05771 4/20 0.41
PRKCA P17252 4/20 0.41
PRKCH P24723 4/20 0.41
PRKCI P41743 4/20 0.41
PRKCE Q02156 4/20 0.41
PRKCQ Q04759 4/20 0.41
PRKCZ Q05513 4/20 0.41
PRKCD Q05655 4/20 0.41
PRKD1 Q15139 4/20 0.41
MEN1 O00255 3/20 0.41
PRKACA P17612 3/20 0.41
PRKACG P22612 3/20 0.41
PRKACB P22694 3/20 0.41
KMT2A Q03164 3/20 0.41
NFKB1 P19838 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6976355 0.87 NPY1R (0.43) NPY1RCYP3A4CYP2D6PRKD3PRKCG
SCHEMBL6968810 0.86 CYP3A4 (0.49) CYP3A4CYP2D6PRKD3PRKCGPRKCB
SCHEMBL6963085 0.85 CYP3A4 (0.44) NPY1RCYP3A4CYP2D6PRKD3PRKCG
SCHEMBL6972256 0.84 CYP3A4 (0.39) NPY1RCYP3A4CYP2D6PRKD3PRKCG
SCHEMBL6977470 0.84 CYP3A4 (0.44) NPY1RCYP3A4CYP2D6PRKD3PRKCG
SCHEMBL6965038 0.82 CYP3A4 (0.44) CYP3A4CYP2D6PRKD3PRKCGPRKCB
Sulfuric Acid SCHEMBL6971001 0.82 CYP3A4 (0.38) NPY1RCYP3A4CYP2D6PRKD3PRKCG
SCHEMBL6966225 0.81 P2RX7 (0.45) CYP3A4CYP2D6PRKD3PRKCGPRKCB
SCHEMBL6966488 0.81 MEN1 (0.44) CYP3A4CYP2D6PRKD3PRKCGPRKCB
SCHEMBL6974826 0.79 CYP3A4 (0.48) CYP3A4CYP2D6PRKD3PRKCGPRKCB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0855391-B1 NOVEL ISOQUINOLINE DERIVATIVES DAIICHI SEIYAKU CO (JP) 2003-10-15 EP disclosed
US-5959107-A Isoquinoline derivatives SNOW BRAND MILK PRODUCTS CO., LTD. (JP) 1999-09-28 US disclosed
EP-0855391-A1 NOVEL ISOQUINOLINE DERIVATIVES SNOW BRAND MILK PRODUCTS CO., LTD. (JP) 1998-07-29 EP disclosed