Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.59 |
| ▸ | CTSS | P25774 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962076 | 1.00 | AAK1 (0.59) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL6961702 | 0.90 | AAK1 (0.57) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL20176308 | 0.88 | AAK1 (0.60) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL16974942 | 0.85 | KMT2A (0.51) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL16974969 | 0.84 | KMT2A (0.50) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL6961705 | 0.82 | CTSS (0.53) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL24064997 | 0.82 | HTT (0.50) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL847723 | 0.80 | KMT2A (0.55) | CTSSMEN1KMT2ANPC1RAB9A | |
| SCHEMBL16970629 | 0.80 | CTSS (0.50) | AAK1CTSSMEN1KMT2ANPC1 | |
| SCHEMBL8981480 | 0.80 | CTSS (0.58) | AAK1CTSSMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | disclosed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |