SCHEMBL6962098

SCHEMBL6962098

ClC/C=C/c1cc2cc(Cl)ccc2s1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.37
LOXL2 Q9Y4K0 1/20 0.35
TUBB4A P04350 2/20 0.33
TUBB P07437 2/20 0.33
TUBA3C P0DPH7 2/20 0.33
TUBA1B P68363 2/20 0.33
TUBA4A P68366 2/20 0.33
TUBB4B P68371 2/20 0.33
TUBB3 Q13509 2/20 0.33
TUBB2A Q13885 2/20 0.33
TUBB8 Q3ZCM7 2/20 0.33
TUBA3E Q6PEY2 2/20 0.33
TUBA1A Q71U36 2/20 0.33
TUBA1C Q9BQE3 2/20 0.33
TUBB6 Q9BUF5 2/20 0.33
TUBB2B Q9BVA1 2/20 0.33
TUBB1 Q9H4B7 2/20 0.33
PRMT1 Q99873 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6962105 1.00 CYP2A6 (0.37) CYP2A6LOXL2TUBB4ATUBBTUBA3C
SCHEMBL6964477 0.85 TUBB4A (0.38) CYP2A6LOXL2TUBB4ATUBBTUBA3C
SCHEMBL6964469 0.85 TUBB4A (0.38) CYP2A6LOXL2TUBB4ATUBBTUBA3C
SCHEMBL6824022 0.79 CYP2A6 (0.38) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL6824024 0.79 CYP2A6 (0.38) CYP2A6TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL6959242 0.78 CYP19A1 (0.43) CYP2A6IDO1
SCHEMBL6959237 0.78 CYP19A1 (0.43) CYP2A6IDO1
SCHEMBL3618744 0.75 CYP2A6 (0.62) CYP2A6LOXL2SMN1; SMN2NPSR1IDO1
SCHEMBL3609679 0.74 ITGB2 (0.42) CYP2A6AKR1B1CHRNA7HTR3AKDM4E
SCHEMBL3609682 0.74 ITGB2 (0.42) CYP2A6AKR1B1CHRNA7HTR3AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974584-B1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-01-15 EP disclosed
US-6420375-B1 ANTITUMOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-16 US disclosed
EP-0974584-A1 FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-01-26 EP disclosed