Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347210 | 0.86 | RIPK3 (0.56) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8714623 | 0.83 | ITGB2 (0.50) | CHEK2STIM1ORAI1ADRA2AADRA2B | |
| SCHEMBL3072409 | 0.80 | ITGB2 (0.55) | CYP3A4CHEK2ITGB2ICAM1ITGAL | |
| SCHEMBL1772593 | 0.79 | CHEK2 (0.46) | CHEK2STIM1ORAI1ADRA2AADRA2B | |
| SCHEMBL30222517 | 0.79 | CHEK2 (0.46) | CHEK2STIM1ORAI1ADRA2AADRA2B | |
| SCHEMBL21207009 | 0.79 | CHEK2 (0.46) | CHEK2STIM1ORAI1ADRA2AADRA2B | |
| SCHEMBL31401569 | 0.77 | PARP1 (0.44) | PIK3CDCYP11B1CYP11B2 | |
| SCHEMBL26658610 | 0.72 | CHEK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9CHEK2 | |
| SCHEMBL29533163 | 0.72 | CHEK2 (0.44) | ROCK2ROCK1CYP3A4CYP2C9CHEK2 | |
| SCHEMBL4835059 | 0.72 | CHEK2 (0.42) | CHEK2STIM1ORAI1ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906912-B1 | Indanol derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-01-08 | — | — | EP | disclosed |
| US-6060487-A | Indanol compounds | ADIR ET COMPAGNIE (FR) | 2000-05-09 | — | — | US | disclosed |
| US-5958927-A | PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1999-09-28 | — | — | US | disclosed |
| CN-1218051-A | New 2,3-dioxide, indanol compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-06-02 | — | — | CN | disclosed |
| EP-0906912-A1 | Indanol derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-04-07 | — | — | EP | disclosed |