Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17165397 | 0.87 | PARP1 (0.37) | PARP1GRM2CCR8KCNH2PDE4B | |
| SCHEMBL28230835 | 0.84 | PARP1 (0.47) | PARP1GRM2KCNH2GYS1 | |
| SCHEMBL14278982 | 0.79 | PARP1 (0.44) | PARP1GRM2MAP4K1HASPINGYS1 | |
| SCHEMBL29677390 | 0.79 | PDE4B (0.34) | PARP1PDE4BCYP11B2CDK1CDK2 | |
| Hydrochloric Acid SCHEMBL3277138 | 0.79 | S1PR1 (0.42) | — | |
| SCHEMBL6962873 | 0.77 | ROCK2 (0.48) | PIK3CDCYP11B2CYP11B1 | |
| SCHEMBL31401040 | 0.76 | PDE4B (0.37) | PDE4BCYP19A1CYP11B2CYP11B1PRF1 | |
| SCHEMBL30820691 | 0.76 | PDE4B (0.32) | PDE4B | |
| SCHEMBL612479 | 0.76 | PDE4B (0.37) | PDE4BCYP19A1CYP11B2CYP11B1PRF1 | |
| SCHEMBL15997877 | 0.74 | PARP1 (0.50) | PARP1GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |