Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.63 |
| ▸ | PDE4A | P27815 | 11/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962818 | 0.84 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6957343 | 0.78 | PDE4A (0.63) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6963380 | 0.78 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6954457 | 0.78 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL6950495 | 0.78 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL1554931 | 0.73 | PDE4D (0.65) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL2671425 | 0.73 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| Hydrochloric Acid SCHEMBL8575508 | 0.73 | PDE4D (0.64) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6173638 | 0.69 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL3944126 | 0.69 | ALDH1A1 (0.46) | PDE4BPDE4APDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944616-B1 | BICYCLIC ARYL CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-06-04 | — | — | EP | disclosed |
| US-20020094987-A1 | Bicyclic aryl carboxamides and their therapeutic use | DYKE HAZEL JOAN (GB) | 2002-07-18 | — | — | US | disclosed |
| US-6353010-B1 | ENZYME INHIBITORS TUMOR NECROSIS FACTOR AND PHOSPHODIESTERASE FOR ANTIINFLAMMATORY AGENTS | DARWIN DISCOVERY, LTD. (GB) | 2002-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020094987-A1 | Bicyclic aryl carboxamides and their therapeutic use | PDE3B, PDE3A, PDE2A | PDE4B 12/4885PDE4A 9/4885PDE4C 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.