Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371402 | 0.86 | MAPK14 (0.41) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL6962798 | 0.80 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL6371399 | 0.79 | MAPK14 (0.43) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL6956938 | 0.77 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL6953493 | 0.76 | MAPK14 (0.64) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL6246309 | 0.74 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL27627756 | 0.72 | MAPK14 (0.45) | MAPK14GCGR | |
| SCHEMBL27627757 | 0.72 | MAPK14 (0.45) | MAPK14GCGR | |
| SCHEMBL6963796 | 0.71 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| SCHEMBL5850335 | 0.68 | MAPK14 (0.65) | MAPK14MAPK11MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178981-B1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | ORTHO MCNEIL PHARM INC (US) | 2003-06-25 | — | — | EP | disclosed |
| US-6562843-B1 | For treating disorders ameliorated by a reduction in TNF-alpha production and/or p38 activity, and are therefore useful for treating inflammatory disorders such as rheumatoid arthritis, as well as AIDS-related disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1178981-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000069847-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-11-23 | — | — | WO | disclosed |