Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.51 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962798 | 0.79 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6953493 | 0.75 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6246309 | 0.74 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5443213 | 0.73 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL4585385 | 0.72 | ALOX5 (0.62) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL14519484 | 0.72 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL5255744 | 0.72 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11NFATC1 | |
| SCHEMBL6077643 | 0.72 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11NFATC1 | |
| SCHEMBL6219428 | 0.71 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11TSHR | |
| SCHEMBL6963552 | 0.71 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178981-B1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | ORTHO MCNEIL PHARM INC (US) | 2003-06-25 | — | — | EP | disclosed |
| US-6562843-B1 | For treating disorders ameliorated by a reduction in TNF-alpha production and/or p38 activity, and are therefore useful for treating inflammatory disorders such as rheumatoid arthritis, as well as AIDS-related disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1178981-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000069847-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-11-23 | — | — | WO | disclosed |