Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964216 | 0.92 | MAPT (0.51) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6958978 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6962997 | 0.86 | RAB9A (0.53) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6962436 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2TDP1KDM4ERAB9ANPC1 | |
| SCHEMBL6962182 | 0.85 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ERAB9ANPC1KMT2A | |
| SCHEMBL6959709 | 0.84 | MAPT (0.49) | SMN1; SMN2KDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL6952011 | 0.84 | RAB9A (0.51) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6962357 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6956833 | 0.81 | MAPT (0.56) | SMN1; SMN2TDP1KDM4EL3MBTL1RAB9A | |
| SCHEMBL6965748 | 0.81 | KMT2A (0.52) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |