Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 8/20 | 0.54 |
| ▸ | NOS3 | P29474 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PAM | P19021 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048336 | 0.84 | TDP1 (0.79) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL7007017 | 0.84 | TDP1 (0.58) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL10853998 | 0.83 | TDP1 (0.56) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL19406969 | 0.83 | TDP1 (0.56) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL28184258 | 0.83 | TDP1 (0.61) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL4829383 | 0.83 | IDO1 (0.58) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL45253 | 0.83 | TDP1 (0.61) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL16596976 | 0.82 | TDP1 (0.51) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL3070200 | 0.81 | IDO1 (0.71) | TDP1L3MBTL1IDO1NOS3NOS1 | |
| SCHEMBL79058 | 0.81 | IDO1 (0.58) | TDP1L3MBTL1IDO1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |