Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964085 | 1.00 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL6964088 | 0.87 | SMN1; SMN2 (0.64) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL11816880 | 0.84 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL6968141 | 0.81 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL6968139 | 0.81 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL3347086 | 0.79 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL12217090 | 0.77 | SMN1; SMN2 (0.61) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL12217099 | 0.77 | SMN1; SMN2 (0.61) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11809428 | 0.75 | KMT2A (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15988688 | 0.74 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2PKMCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169317-B1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6465493-B1 | SUCH AS 4-(4-(4-FLUOROPHENYL)-5-(2-PYRIDYL)-1-HYDROXY-1H-IMIDAZOL-2-YL)BENZONITRILE; ALK5 MEDIATED DISEASES SUCH AS ARTHRITIS, OSTEOPOROSIS, KIDNEY AND RENAL DISEASES, CONGES-TIVE HEART FAILURE, ULCERS, DIABETIC NEPHROPATHY | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | disclosed |
| EP-1169317-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061576-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-19 | — | — | WO | disclosed |