Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.71 |
| ▸ | RAB9A | P51151 | 7/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-(Phenoxymethyl)Benzothiazole SCHEMBL2245843 | 0.84 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL7541252 | 0.81 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| Cyanide SCHEMBL25382173 | 0.80 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8136532 | 0.79 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL7544788 | 0.78 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL1711724 | 0.78 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL22735662 | 0.77 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8769691 | 0.76 | EPHX2 (0.84) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL324660 | 0.76 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| 2-(Phenoxymethyl)Benzothiazole SCHEMBL8666960 | 0.76 | NPC1 (0.83) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902007-B1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2003-11-05 | — | — | EP | disclosed |
| US-6046212-A | ANTIALLERGIC AGENTS | KOWA CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0902007-A1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1999-03-17 | — | — | EP | disclosed |