Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | IL6 | P05231 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960258 | 0.92 | PPARG (0.34) | PPARGPPARAGSK3BHTTMAPT | |
| SCHEMBL6963879 | 0.91 | GSK3B (0.34) | PPARGPPARAGSK3BPTGS1PTGS2 | |
| SCHEMBL6966164 | 0.89 | PPARG (0.32) | PPARGPPARAGSK3BPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL6964518 | 0.88 | PPARG (0.32) | PPARGPPARAGSK3BPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL6958992 | 0.84 | PPARG (0.34) | PPARGPPARAPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL6965523 | 0.83 | ALDH1A1 (0.33) | PPARGPPARAPTGS1PTGS2 | |
| SCHEMBL6959448 | 0.83 | PPARG (0.36) | PPARGPPARAPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL6956171 | 0.82 | ALDH1A1 (0.33) | PPARGPPARA | |
| SCHEMBL6960256 | 0.81 | PPARG (0.36) | PPARGPPARAGSK3BPTGS1KMT2A | |
| Hydrochloric Acid SCHEMBL6965517 | 0.81 | PPARG (0.35) | PPARGPPARAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971709-B1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | LILLY CO ELI (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-1999018091-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0908454-A2 | Oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |