⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969380 | 0.80 | — | — | |
| SCHEMBL20213914 | 0.69 | NPC1 (0.31) | — | |
| SCHEMBL2176892 | 0.57 | — | — | |
| SCHEMBL2039394 | 0.53 | — | — | |
| SCHEMBL19580748 | 0.53 | — | — | |
| SCHEMBL345629 | 0.53 | — | — | |
| SCHEMBL2136755 | 0.53 | — | — | |
| SCHEMBL15161854 | 0.53 | — | — | |
| SCHEMBL10273176 | 0.49 | — | — | |
| SCHEMBL22278145 | 0.41 | HTR2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | claimed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | claimed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | claimed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | claimed |
| US-20240092819-A1 | NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR | SANOFI SA (FR) | 2024-03-21 | — | — | US | disclosed |
| US-11891386-B2 | Indole compounds and their use | ARIAGEN, INC. (CA) | 2024-02-06 | — | — | US | disclosed |
| US-20230145074-A1 | Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230054194-A1 | Methods of Treating Cancer | ARIAGEN, INC. (US) | 2023-02-23 | — | — | US | disclosed |
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2022-12-08 | — | — | US | disclosed |
| US-11459322-B2 | Indole compounds and their use | ARIAGEN, INC. (US) | 2022-10-04 | — | — | US | disclosed |
| US-11390621-B2 | Chiral indole compounds and their use | ARIAGEN, INC. (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3956327-A1 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | Ariagen, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020214740-A9 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| US-20200354353-A1 | Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2020-11-12 | — | — | US | disclosed |
| WO-2020214740-A1 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-3713937-A2 | INDOLE COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) MODULATORS | Ariagen, Inc. (US) | 2020-09-30 | — | — | EP | disclosed |
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |