SCHEMBL6964952

SCHEMBL6964952

[O]C(=O)C(F)Cc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.54
ALPI P09923 1/20 0.50
PKM P14618 1/20 0.50
PTGS1 P23219 1/20 0.50
XIAP P98170 1/20 0.50
SLC7A5 Q01650 1/20 0.50
MDM2 Q00987 1/20 0.48
CPA1 P15085 3/20 0.47
CPA3 P15088 3/20 0.47
FOLH1 Q04609 1/20 0.47
CPB1 P15086 1/20 0.47
CPB2 Q96IY4 1/20 0.47
SRR Q9GZT4 2/20 0.46
EPHX1 P07099 2/20 0.46
SLC1A3 P43003 1/20 0.46
SLC1A2 P43004 1/20 0.46
SLC1A1 P43005 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KEAP1 Q14145 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28090728 0.84 CYP1A2 (0.56) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL246475 0.84 CYP1A2 (0.61) CYP1A2ALPIPKMPTGS1XIAP
Ammonia Solution, Strong SCHEMBL38660546 0.83 CYP1A2 (0.59) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL7810193 0.81 CYP1A2 (0.52) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL12271851 0.81 CYP1A2 (0.57) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL28529489 0.81 ALPI (0.53) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL29020043 0.81 EPHX1 (0.58) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL3697928 0.79 MDM2 (0.66) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL166489 0.78 CYP1A2 (0.48) CYP1A2ALPIPKMPTGS1XIAP
SCHEMBL7279699 0.78 ATM (0.54) CYP1A2NPC1RAB9AHSD17B10POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329160-A2 4-ACYLAMINOPYRAZOLE DERIVATIVES Sankyo Company, Limited (JP) 2003-07-23 EP disclosed